Zutaten: Bromelain, Kurkumawurzelstockextrakt 50:1 (Curcuma longa, enthält 95 % Curcuminoide), Überzugsmittel: Hydroxypropylmethylcellulose (pflanzliche Kapselhülle), Chinesischer Goldfadenwurzelextrakt 25:1 (Coptis chinensis, enthält 50 % Berberine), schwarzpfefferextrakt (enthält 95 % Piperin)

*Prozent der empfohlenen täglichen Verzehrmenge laut Verordnung (EU) Nr. 1196/2011

**Keine Nährstoffbezugswerte (NRV) vorhanden.

Die angegebene empfohlene tägliche Verzehrsmenge darf nicht überschritten werden. Nahrungsergänzungsmittel sollten nicht als Ersatz für eine ausgewogene und abwechslungsreiche Ernährung verwendet werden. Das Produkt ist außerhalb der Reichweite von kleinen Kindern zu lagern.

1. Walsh NP, Gleeson M, Shephard RJ, et al. Position statement. Part one: Immune function and exercise. Exerc Immunol Rev. 2011;17:6-63.
2. Paulsen G, Mikkelsen UR, Raastad T, et al. Leucocytes, cytokines and satellite cells: what role do they play in muscle damage and regeneration following eccentric exercise? Exerc Immunol Rev. 2012;18:42-97.
3. Febbraio MA, Pedersen BK. Contraction-induced myokine production and release: is skeletal muscle an endocrine organ? Exerc Sport Sci Rev. 2005;33(3):114-119.
4. Tidball JG. Inflammatory processes in muscle injury and repair. Am J Physiol Regul Integr Comp Physiol. 2005;288(2):R345-R353.
5. Hittel DS, Berggren JR, Shearer J, Boyle K, Houmard JA. Increased secretion and expression of myostatin in skeletal muscle from extremely obese women. Diabetes. 2009;58(1):30-38.
6. Herder C, Schneitler S, Rathmann W, et al. Low-grade inflammation, obesity, and insulin resistance in adolescents. J Clin Endocrinol Metab. 2007;92(12):4569-4574.
7. Pradhan AD, Manson JE, Rifai N, Buring JE, Ridker PM. C-reactive protein, interleukin 6, and risk of developing type 2 diabetes mellitus. JAMA. 2001;286(3):327-334.
8. Ridker PM, Buring JE, Cook NR, Rifai N. C-reactive protein, the metabolic syndrome, and risk of incident cardiovascular events: an 8-year follow-up of 14 719 initially healthy American women. Circulation. 2003;107(3):391-397.
9. Ford ES, Giles WH, Mokdad AH, Myers GL. Distribution and correlates of C-reactive protein concentrations among adult US women. Clin Chem. 2004;50(3):574-581.
10. Engelhart MJ, Geerlings MI, Meijer J, et al. Inflammatory proteins in plasma and the risk of dementia: the Rotterdam Study. Arch Neurol. 2004;61(5):668-672.
11. Lai SW, Chen JH, Lin HY, Liu CS, Li TC, Tsai CF. Increased risk of dementia in patients with osteoporosis: a population-based retrospective cohort analysis. Age (Dordr). 2014;36(1):363-370.
12. Brien S, Lewith GT, et al. Bromelain as an adjunctive treatment for osteoarthritis of the knee: a randomized controlled pilot study. QJM. 2006;99(12):841-850. doi: 10.1093/qjmed/hcl119
13. Hale LP, Greer PK, Trinh CT, et al. Treatment with oral bromelain decreases colonic inflammation in the IL-10-deficient murine model of inflammatory bowel disease. Clin Immunol. 2005;116(2):135-142. doi: 10.1016/j.clim.2005.03.003
14. Maurer HR. Bromelain: biochemistry, pharmacology and medical use. Cell Mol Life Sci. 2001;58(9):1234-1245. doi: 10.1007/PL00000936
15. Miller PC, Bailey SP, Barnes ME, et al. The effects of protease supplementation on skeletal muscle function and DOMS following downhill running. J Sports Sci. 2004;22(4):365-372. doi: 10.1080/02640410310001655881
16. Secor ER Jr, Singh A, et al. Bromelain treatment reduces CD25 expression on activated CD4+ T cells in vitro. Int Immunopharmacol. 2009;9(3):340-346. doi: 10.1016/j.intimp.2008.11.007
17. Kheirouri S, Alizadeh M. Berberine natural alkaloid improves diabetic retinopathy through modulation of oxidative stress, inflammation and gene expression. Biomed Pharmacother. 2019;109:547-557. doi: 10.1016/j.biopha.2018.10.012
18. Zhou Y, Ren Y, Zhang X, et al. Berberine hydrochloride attenuates lipopolysaccharide-induced endometritis in mice via suppression of the TLR4/NF-κB signaling pathway. Drug Des Devel Ther. 2018;12:775-783. doi: 10.2147/DDDT.S158337
19. Jurenka JS. Anti-inflammatory properties of curcumin, a major constituent of Curcuma longa: a review of preclinical and clinical research. Altern Med Rev. 2009;14(2):141-153. PMID: 19594223.
20. Daily JW, Yang M, et al. Efficacy of turmeric extracts and curcumin for alleviating the symptoms of joint arthritis: a systematic review and meta-analysis of randomized clinical trials. J Med Food. 2016;19(8):717-729. doi: 10.1089/jmf.2016.3705
21. Kuptniratsaikul V, Dajpratham P, et al. Efficacy and safety of Curcuma domestica extracts compared with ibuprofen in patients with knee osteoarthritis: a multicenter study. Clin Interv Aging. 2014;9:451-458. doi: 10.2147/CIA.S58535
22. Chainani-Wu N. Safety and anti-inflammatory activity of curcumin: a component of tumeric (Curcuma longa). J Altern Complement Med. 2003 Feb;9(1):161-8. doi: 10.1089/107555303321223035. PMID: 12676044.
23. Aggarwal BB, Harikumar KB. Potential therapeutic effects of curcumin, the anti-inflammatory agent, against neurodegenerative, cardiovascular, pulmonary, metabolic, autoimmune and neoplastic diseases. Int J Biochem Cell Biol. 2009 Jan;41(1):40-59. doi: 10.1016/j.biocel.2008.06.010. Epub 2008 Jun 25. PMID: 18662800.
24. Jobin C, Bradham CA, Russo MP, Juma B, Narula AS, Brenner DA, Sartor RB. Curcumin blocks cytokine-mediated NF-kappa B activation and proinflammatory gene expression by inhibiting inhibitory factor I-kappa B kinase activity. J Immunol. 1999 May 1;163(9):3474-83. PMID: 10553082.